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Inhibition of therapeutic protein aggregation by cyclodextrins

By Tim Serno

Inhibition of therapeutic protein aggregation by cyclodextrins Medicine

Inhibition of therapeutic protein aggregation by cyclodextrins

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Description
Advances in molecular genetics and recombinant protein (rDNA) technology lead to anincreasing availability of protein-based biomolecules1. In contrast to conventional lowmolecular weight synthetic chemical drugs protein drugs provide a relatively high specifityand activity at low concentrations2. Therefore, today protein drugs represent a fast-growingclass of therapeutic molecules1,3. Protein-based drugs offer a multitude of new therapeuticoptions, mainly for the treatment of severe and chronic diseases such as autoimmune orcancer diseases2. However, with the increasing number of "new biologic entities" passingthrough development and manufacturing and finally reaching patients, also unprecedentedchallenges for the design of stable, safe and convenient formulations are encountered4.The first obvious formulation challenge to be faced concerns the delivery of protein drugs.Oral delivery - which is generally the preferred and most widely applied route of drugadministration - is not feasible with protein drugs.
Product details
Binding:
Paperback
Edition:
1
Number of Pages:
244
Release Date:
2011-02-03
Publication Date:
2011-02-03
Publisher:
Cuvillier
Languages:
Original: English
ISBN10:
3869556315
ISBN13:
9783869556314
GPSR Manufacturer Reference:
[email protected]
Weight:
321 g
Height:
148 cm
Width:
210 cm
Thickness:
13 cm
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Very good
Almost no signs of wear. Book pages have no markings, accessories are intact and all other media are in good condition.
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