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Synthesis and Structural Annotation of Organotin(IV) Derivatives

By Saira Shahzadi

Synthesis and Structural Annotation of Organotin(IV) Derivatives Natural Sciences

Synthesis and Structural Annotation of Organotin(IV) Derivatives

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Description
The research work has been divided into two parts. In Part A, various di- and triorganotin(IV) compounds have been synthesized by reactions of R2SnCl2, R2SnO and R3SnCl with a stoichiometric amount of synthesized carboxylic acid. In Part B, various di-, tri- and chlorodiorganotin(IV) thiocarboxylates have been synthesized by the reaction of di- and triorganotin(IV) chlorides with thiocarboxylic acid in stoichiometric amount in dry toluene under reflux conditions. The structural assignments were made on the basis of spectral techniques such as FT-IR, 1H, 13C, 119Sn NMR, mass spectrometry and XRD which ascertain the tetrahedral environment around the tin atom in solution, while penta or hexa coordination is found in the solid state. Biological activity tests of the synthesized carboxylates and thiocarboxylates were made against various medically important bacteria, fungi, insects and leishmania. Most of the compounds were found to show activity with a few exceptions. These compounds were also evaluated for their cytotoxicity using the brine-shrimp lethality bioassay method. Only few of the compounds were found to be nontoxic.
Product details
Binding:
Paperback
Number of Pages:
336
Release Date:
2011-03-31
Publication Date:
2013-11-21
Publisher:
LAP Lambert Academic Publishing
Languages:
Original: English
ISBN10:
384337337X
ISBN13:
9783843373371
Weight:
518 g
Height:
150 cm
Width:
220 cm
Thickness:
20 cm
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