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Razoxane and Dexrazoxane - Two Multifunctional Agents
- Used - good
Description
They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc.
The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer¿s disease could be stabilized by one or both these drugs.
Product details
Edition:
1
Number of Pages:
260
Release Date:
2010-10-06
Publication Date:
2010-10-06
Publisher:
Springer
Languages:
Original:
English
ISBN10:
904819167X
ISBN13:
9789048191673
GPSR Manufacturer Reference:
Weight:
606 g
Height:
160 cm
Width:
241 cm
Thickness:
21 cm
Preview Link:
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