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Asymmetric Baeyer-Villiger Oxidations Using Biocatalysts.

By Radka Snajdrova

Asymmetric Baeyer-Villiger Oxidations Using Biocatalysts. Natural Sciences

Asymmetric Baeyer-Villiger Oxidations Using Biocatalysts.

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Description
Chiral lactones are important building blocks in organic synthesis. A broad range of useful products are accessible via enantioselective Baeyer-Villiger oxidation of simple ketones. Such lactones can serve as versatile building blocks in natural product and bioactive compound synthesis.For the transformation of achiral ketones to chiral lactones, Baeyer-Villiger monooxygenases (BVMOs) were utilized, since these enzymes exhibit wide substrate specificity and high enantioselectivity. The advantage of this approach is that BVMOs can generate several chiral centers in a single biotransformation step. Various cofactor recycling options have also been considered during this study. As a direct consequence of this research, a metabolically independent biocatalyst was developed, which performs cofactor regeneration concomitantly with the oxygenation reaction. . Such a system is very attractive for industrial applications as operational costs are dramatically reduced due to the absence for the requirement of co-factor recycling.
Product details
Binding:
Paperback
Number of Pages:
288
Release Date:
2009-08-16
Publication Date:
2009-09-09
Publisher:
VDM Verlag Dr. Müller e.K.
Languages:
Original: English
ISBN10:
3639192656
ISBN13:
9783639192650
Weight:
447 g
Height:
150 cm
Width:
220 cm
Thickness:
17 cm
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