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Proanthocyanidin against convulsion and cognitive impairment

By Opeyemi Osuntokun

Proanthocyanidin against convulsion and cognitive impairment Medicine

Proanthocyanidin against convulsion and cognitive impairment

0 - Default Title
Description
Convulsive status epilepticus is arguably one of the most debilitating neurological disorder, characterized by prolong episode of seizures. It is worthy of note that brain diseases pose the largest health, economic, and social capital burden worldwide of any disease group. This study has explored the potential effects of proanthocyanidin rich fraction (PRF) obtained from grape seed on the central nervous system particularly in convulsive status epilepticus (CSE) model. In this study, a significant brain and hippocampus atrophy, increased malondialdehyde concentration, increased hippocampus glial cells and granule count, exacerbated activities of acetylcholinesterase and increased indices of neuroinflammation following CSE induction are consistent with the hippocampus-dependent memory impairment observed observed among the convulsed mice. However, most of these aberrations including alteration of cholinergic neurotransmitters, astrogliosis, hippocampus toxicity, neuroinflammation, and neuronal necrosis were ameliorated following PRF treatment, a result similar to what was obtainable in the group treated with a standard drug, diazepam.
Product details
Binding:
Paperback
Number of Pages:
224
Release Date:
2025-11-07
Publication Date:
2025-11-07
Publisher:
LAP LAMBERT Academic Publishing
Languages:
Original: English
ISBN10:
6209246133
ISBN13:
9786209246135
Weight:
352 g
Height:
150 cm
Width:
220 cm
Thickness:
14 cm
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