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The influence of glycation on neuroblastoma cells

By Maximilian Scheer

The influence of glycation on neuroblastoma cells Medicine

The influence of glycation on neuroblastoma cells

0 - Default Title
Description
High glucose levels, such as those found in diabetes mellitus, promote the glycation of proteins and lead to the formation of AGEs. These AGEs accelerate aging processes and are associated with micro- and macrovascular complications as well as neurodegenerative diseases. Many effects are receptor-dependent, with RAGE considered one of the most important interaction partners for AGEs. Treatment of Kelly-type neuroblastoma cells with MGO, the most potent precursor of AGE formation, did not result in a reduction in cell viability. After treatment, increased formation of CML and Western blot was observed. Furthermore, glycated cells showed clear signals for CML and RAGE in flow cytometry. Glycation of matrix proteins led to a reduction in adhesion to laminin in RTCA, but had no effect on fibronectin and collagen IV. In addition, an increased migration rate was detected due to glycation of the cells.
Product details
Binding:
Paperback
Number of Pages:
80
Release Date:
2025-06-20
Publication Date:
2025-06-20
Publisher:
Our Knowledge Publishing
Languages:
Original: English
ISBN10:
620898341X
ISBN13:
9786208983413
GPSR Manufacturer Reference:
[email protected]
Weight:
137 g
Height:
150 cm
Width:
220 cm
Thickness:
5 cm
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