Roles of clpA and clpB in the virulence of Salmonella Typhimurium

Name: Roles of clpA and clpB in the virulence of Salmonella Typhimurium
Brand: LAP LAMBERT Academic Publishing
Availability: OutOfStock
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By Lal Sangpuii

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Description

Salmonella Typhimurium encounters several stress, including oxidants generated by the phagocytes and higher (42 °C) body temperature inside the poultry host.To withstand such assaults, three types of energy dependant proteases, including the caseinolytic proteases (Clps) family (viz. ClpA, ClpB, ClpX, ClpP), Lon and HslVU are reported in S. Typhimurium. In the current study, comparative roles of two such Clps, clpA (involved in proteolysis) and clpB (involved in protein disaggregation and refolding) in the survival of S. Typhimurium under different stresses and in virulence have been investigated. We deleted clpA and clpB genes (¿clpA and ¿clpB) from S. Typhimurium and then complemented in trans by pQE60 plasmid. ¿clpB strain was comparatively much more susceptible to 42 °C, HOCl, paraquat and macrophage than ¿clpA strain. As compared to WT and ¿clpA strains, ¿clpB strain was defective for colonization in the poultry caecum and showed decreased dissemination to spleen and liver. Therefore, ClpB is more important than ClpA for survival of S. Typhimurium under stress and virulence in poultry.

Product details

Binding:: Paperback
Number of Pages:: 104
Release Date:: 2025-11-03
Publication Date:: 2025-11-03
Publisher:: LAP LAMBERT Academic Publishing
Languages:: Original: English
ISBN10:: 6209170773
ISBN13:: 9786209170775
GPSR Manufacturer Reference:: [email protected]
Weight:: 173 g
Height:: 15 cm
Width:: 22 cm
Thickness:: 0.7 cm

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