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Pathophilosophy of Human Disease - Autoimmune Disease

By Ravikumar Kurup

Pathophilosophy of Human Disease - Autoimmune Disease

0 - Default Title
Description
Modern civilization results in stress in societies leading to increased activation of the HPA axis leading to increased secretion of stress hormones the catecholamines producing increase in sympathetic tone. The increase in sympathetic tone leads to increase in stress hormones epinephrine and norepinephrine producing breeching of the gut blood barrier. This leads to decrease in mucin secretion lining the gut wall and inflammatory changes in the colonic mucosa. Modern civilization results in changes in dietary habits leading to less consumption of fibre and more intake of protein and fat. This leads to increased colonic archaeal growth and archaeal endosymbiosis. The endosymbiotic archaeal growth leads to a new neanderthalic phenotype as a stress adaptation syndrome. The archaeal endosymbiosis leads to the induction of a new metabolic phenotype with mitochondrial dysfunction and anaerobic glycolysis- the Warburg phenotype. The Warburg phenotype produces immune activation consequent to increased lymphocytic glycolysis producing autoimmune disease.
Product details
Binding:
Paperback
Number of Pages:
100
Release Date:
2025-11-03
Publication Date:
2025-11-03
Publisher:
LAP LAMBERT Academic Publishing
Languages:
Original: English
ISBN10:
6209183301
ISBN13:
9786209183300
Weight:
167 g
Height:
150 cm
Width:
220 cm
Thickness:
6 cm
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