Placeholder text

Go to cart

Murine Interferon Regulatory Factor-2 (IRF-2) and Escherichia coli

By Krishna Prakash

Murine Interferon Regulatory Factor-2 (IRF-2) and Escherichia coli

By Krishna Prakash

0 - Default Title
Description
Interferon Regulatory Factor-2 is a vertebrate transcription factor having oncogenic nature; it antagonises Interferon Regulatory Factor-1, a tumor suppressor gene, functions. Knockout mice for IRF-2 gene showed defect in B-cell lymphopoeisis, they died following LCMV (Lymphocytic Choriomeningitis Virus) infections. IRF-2 is functionally just opposite of IRF-1. Interestingly, one would have thought that as IRF-1-/- (knock-out) mice showed lack of CD8+T cells and low cytotoxicity of NK cells, the over production of IRF-2 in mice may restore it. But it does not happen so, the reason being unknown. However, IRF-2 binds at Interferon Stimulated Response Element sequence in viral infected cell. This book is about mouse IRF-2 gene cDNA cloning and expression of chimeric protein in E.coli. This study will serve as a platform for further functional analysis of chimeric IRF-2, which is potent oncogene in aberrant conditions.
Product details
Binding:
Paperback
Number of Pages:
116
Release Date:
2025-11-03
Publication Date:
2025-11-03
Publisher:
LAP LAMBERT Academic Publishing
Languages:
Original: English
ISBN10:
6209184553
ISBN13:
9786209184550
Weight:
191 g
Height:
150 cm
Width:
220 cm
Thickness:
7 cm
Buy on Amazon
Currently sold out