Placeholder text

Go to cart

Tef1 is a multifunctional protein of Candida albicans

By Justus Linden

Tef1 is a multifunctional protein of Candida albicans Medicine

Tef1 is a multifunctional protein of Candida albicans

0 - Default Title
Description
This study is the first to demonstrate at the cellular level the contribution of a single surface protein to complement and immune evasion by Candida albicans. Tef1 (translation elongation factor 1) is a moonlighting protein of C. albicans. It is expressed on the cell surface, secreted, and also localized in the cytoplasm as a translation factor. Tef1 acts both as CRASP (complement regulator acquiring surface protein) directly at the site of expression and as a secreted protein away from the fungal cell surface. Tef1 binds to cells and components of the innate immune system and also influences the adaptive immune system, especially B cells. Overall, Tef1 is a multifactorial immune evasion protein of C. albicans. Its moonlighting characteristic as a surface and secreted protein allows Tef1 to modulate both the innate (complement cascade) and adaptive immune responses (B cells). Thus, Tef1 enables the persistence of C. albicans in the human organism in a variety of ways.
Product details
Binding:
Paperback
Number of Pages:
108
Release Date:
2025-06-25
Publication Date:
2025-06-25
Publisher:
Our Knowledge Publishing
Languages:
Original: English
ISBN10:
6203573221
ISBN13:
9786203573220
Weight:
179 g
Height:
150 cm
Width:
220 cm
Thickness:
7 cm
Buy on Amazon
Currently sold out