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Many a Tear has to Fall

By Joan Jonker

Product Image: Many a Tear has to Fall

Many a Tear has to Fall

By Joan Jonker

Only 1 item left in stock
Description
The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry. TOC:G.G. Wu, M. Huang: Organolithium in Asymmetric Processes.- D.L. Hughes: Applications of Organotitanium Reagents.- K. Sumi, H. Kumobayashi: Rhodium/Ruthenium Applications.- A.J. Delmonte, E.D. Dowdy and D.J. Watson: Development of Transition Metal-Mediated Cyclopropanation Reactions.- J.F. Larrow, E.N. Jacobsen: Asymmetric Processes Catalyzed by Chiral (Salen)Metal Complexes.- S.J. Mehrman, A.F. Abdel-Magid, C.A. Maryanoff and B.P. Medaer: Non-Salen Metal-Catalyzed Asymmetric Dihydroxylation and Asymmetric Aminohydroxylation of Alkenes. Practical Applications and Recent Advances.- M. Prashad: Palladium-Catalyzed Heck Arylations in the Synthesis of Active Pharmaceutical Ingredients.- A.O. King, N. Yasuda: Palladium-Catalyzed Cross-Coupling Reactions in the Synthesis of Pharmaceuticals.- J. Kant: Stereospecific Introduction of Cephalosporin Side Chains Employing Transition Metal Complexes.- J.T. Bien, G.C. Lane and M.R. Oberholzer: Removal of Metals from Process Streams: Methodologies and Applications
Product details
Binding:
Paperback
Edition:
1
Number of Pages:
512
Release Date:
2001-04-05
Publication Date:
2001-04-05
Publisher:
Headline Publishing Group
Languages:
Original: English
ISBN10:
0747266131
ISBN13:
9780747266136
GPSR Manufacturer Reference:
[email protected]
Weight:
319 g
Height:
111 cm
Width:
185 cm
Thickness:
35 cm

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