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Topical Pluronic Lecithin Organogel for Pain Management

By Vikas Jhawat

Topical Pluronic Lecithin Organogel for Pain Management Medicine

Topical Pluronic Lecithin Organogel for Pain Management

0 - Default Title
Description
Pluronic lecithin based organogels were formulated as topical carrier for controlled delivery of mefenamic acid, an analgesic and anti-inflammatory drug practically insoluble in water. The organogels were prepared by method employing lecithin and pluronic as oil phase and aqueous phase respectively. Isopropyl myristate (IPM) was used as organic solvent for lecithin, whereas gelation was achieved by slowly addition of aqueous phase (Pluronic). Ten formulations were prepared using varying concentration of lecithin and pluronic. Increase in the amount of lecithin resulted in organogels with higher viscosity and lower spreadability and same pattern was followed when pluronic with varying concentrations was used. Organogels with higher viscosity were found to be more stable and controlling the release rate. All formulations were found to have pH value within the range of 5.56-5.80 i.e. within skin pH range. So none of the formulations were found irritant to the skin. In vitro release of mefenamic acid from organogels showed that organogels containing 2% lecithin (F2) gave highest release in 8 hours.
Product details
Binding:
Paperback
Number of Pages:
164
Publication Date:
2023-10-24
Publisher:
LAP LAMBERT Academic Publishing
Languages:
Original: English
ISBN10:
6206789519
ISBN13:
9786206789512
GPSR Manufacturer Reference:
[email protected]
Weight:
262 g
Height:
150 cm
Width:
220 cm
Thickness:
10 cm
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