Mitochondria in Health and Diseases

Name: Mitochondria in Health and Diseases
Brand: MDPI AG
Availability: OutOfStock
Rating: 5 (1 reviews)

By Sabzali Javadov

0 - Default Title

Description

Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.

Product details

Number of Pages:: 434
Release Date:: 2020-09-04
Publication Date:: 2020-09-04
Publisher:: MDPI AG
Languages:: Original: English
ISBN10:: 3039363840
ISBN13:: 9783039363841
GPSR Manufacturer Reference:: [email protected]
Weight:: 1284 g
Height:: 175 cm
Width:: 250 cm
Thickness:: 32 cm

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