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Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer

By Indumathi Nandhakumar

Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer Law

Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer

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Description
This study explores the expression of Yes-associated protein (YAP), a key effector of the Hippo pathway, across the spectrum of oral carcinogenesis. Using immunohistochemistry on ethically sourced samples of normal oral mucosa, leukoplakia, and oral squamous cell carcinoma (OSCC), we observed a clear, progressive rise in YAP staining from healthy tissue to dysplasia and finally to OSCC. Dysplastic lesions showed stepwise increases in YAP intensity correlating with severity, while OSCC displayed the highest expression. Both nuclear and cytoplasmic staining were evident, with nuclear positivity (>10%) highlighting YAP's active transcriptional role in promoting cell growth and malignant transformation. These findings suggest that YAP is a significant biomarker and potential driver of oral cancer progression.
Product details
Binding:
Paperback
Number of Pages:
84
Release Date:
2025-12-12
Publication Date:
2025-12-12
Publisher:
LAP LAMBERT Academic Publishing
Languages:
Original: English
ISBN10:
6209363520
ISBN13:
9786209363528
Weight:
143 g
Height:
150 cm
Width:
220 cm
Thickness:
6 cm
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