Lipogenesis of the arterial wall

Name: Lipogenesis of the arterial wall
Brand: Our Knowledge Publishing
Availability: OutOfStock
Rating: 5 (1 reviews)

By Nadjiba Hamlat-Khennaf

0 - Default Title

Description

ARTERIAL WALL LIPOGENESIS: REGULATION OF ITS EXPRESSION AND ANOMALIES IN INSULIN RESISTANCE AND DIABETES We studied the expression and regulation of lipogenesis in aortas and CMLV and determined whether it is altered by insulin resistance and diabetes. Obese Zucker (ZO) rats, diabetic rats, and Psammomys obesus rats accumulate more lipids in their aortas than their controls. However, the expression of lipogenesis genes and those involved in fatty acid uptake is not increased. A similar result was found in human endarterectomy specimens. The adipogenic environment, glucose, or insulin alone moderately stimulate lipogenesis only in control Zucker CMLs; no effect was observed in ZO CMLs. We have shown that the effects of TO901317 on lipogenesis in CMLV are due solely to the activation of the nuclear receptor LXR¿; PXR has no effect. In conclusion, lipogenesis is not increased in the arterial wall during insulin resistance and diabetes.

Product details

Binding:: Paperback
Number of Pages:: 128
Release Date:: 2026-01-29
Publication Date:: 2026-01-29
Publisher:: Our Knowledge Publishing
Languages:: Original: English
ISBN10:: 6209551424
ISBN13:: 9786209551420
GPSR Manufacturer Reference:: [email protected]
Weight:: 209 g
Height:: 15 cm
Width:: 22 cm
Thickness:: 0.8 cm

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