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Mechanism of Bone Destruction

By Shivani Gupta

Mechanism of Bone Destruction

By Shivani Gupta

- Default Title
Description
Bone destruction is central to conditions like osteoporosis, rheumatoid arthritis, and cancers with bone metastases. It results from an imbalance between bone resorption by osteoclasts and formation by osteoblasts. Osteoclast activity is regulated by the RANK/RANKL/OPG axis, where an increased RANKL/OPG ratio promotes osteoclastogenesis. Inflammatory cytokines (e.g., TNF-¿, IL-1, IL-6) enhance RANKL expression and osteoclast survival. In cancer, tumor-derived factors like PTHrP and prostaglandins further drive RANKL-mediated bone loss. Bone resorption releases growth factors such as TGF-ß, fueling tumor growth and perpetuating degradation. Enzymes like MMPs and cathepsin K degrade bone matrix, while hypoxia and mechanical stress also contribute. Understanding these mechanisms supports treatments like bisphosphonates, RANKL inhibitors (e.g., denosumab), and anti-cytokine therapies, which effectively reduce bone loss.
Product details
Binding:
Paperback
Number of Pages:
88
Release Date:
2025-06-06
Publication Date:
2025-06-06
Publisher:
LAP LAMBERT Academic Publishing
Languages:
Original: English
ISBN10:
620844523X
ISBN13:
9786208445232
GPSR Manufacturer Reference:
[email protected]
Weight:
149 g
Height:
150 cm
Width:
220 cm
Thickness:
6 cm
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