Placeholder text

Go to cart

RNA Editing

By Ivo Fierro-Monti

RNA Editing

By Ivo Fierro-Monti

0 - Default Title
Description
Currently an EMBL-Marie Curie Fellow at the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) in Cambridgeshire, UK, a biochemist with extensive research experience in RNA biology across multiple global institutions. His work focuses on RNA-binding proteins in the contexts of signalling, translation control, and gene expression regulation, utilising proteomics, proteogenomics, and interactome analysis to explore mechanisms relevant to both health and disease. RBPs, as highlighted in the manuscript, occupy a crucial position in the intricate network of gene expression regulation. Through their dynamic interactions with RNA molecules, RBPs play essential roles in diverse cellular processes, including mRNA splicing, transport, stability, and translation. Dysregulation of RBPs has been implicated in various diseases, ranging from cancer to neurodegenerative disorders, underscoring their significance in maintaining cellular homeostasis. The book delves into recent evidence suggesting that RBPs are not only targets of post-transcriptional RNA editing but also actively participate in the editing process. Specifically, the book explores the prevalence of A-to-I RNA editing events within transcripts encoding RBPs, mediated by double-stranded RNA-binding proteins (dsRBPs) with Adenosine Deaminase Acting on double-stranded (ds)RNA (ADAR) enzymatic activity. This observation challenges conventional notions of RNA editing primarily occurring in non-coding regions and underscores the importance of considering coding region editing events in the context of RBPs. Functional consequences of RNA editing on RBPs are described, including alterations in protein isoforms, amino acid sequence modifications, and changes in protein-protein interactions. A comprehensive analysis of high-throughput datasets and a prototype proteogenomic approach, provide insights into the impact of RNA editing on the recoded proteome and its implications in potential disease development.Of particular interest are the identification of disease-associated RNA editing events within transcripts encoding RBPs, highlighting the potential role of RNA.
Product details
Binding:
Paperback
Number of Pages:
42
Release Date:
2024-08-27
Publication Date:
2024-07-14
Publisher:
Eliva Press
Languages:
Original: English
ISBN10:
1636487505
ISBN13:
9781636487502
Weight:
78 g
Height:
152 cm
Width:
229 cm
Thickness:
3 cm
Buy on Amazon
Currently sold out