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Cellular Peptide Hormone Synthesis and Secretory Pathways

By Rehfeld, Jens F.

Cellular Peptide Hormone Synthesis and Secretory Pathways

By Rehfeld, Jens F.

0 - Default Title
Description
The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones ¿ including the old master hormone insulin ¿ represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.
Product details
Edition:
1
Number of Pages:
248
Release Date:
2010-03-11
Publication Date:
2010-03-11
Publisher:
Springer Berlin Heidelberg
Languages:
Original: English
ISBN10:
3642118348
ISBN13:
9783642118340
GPSR Manufacturer Reference:
[email protected]
Weight:
587 g
Height:
160 cm
Width:
241 cm
Thickness:
20 cm
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