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L-Carnitine and DNA

By Luz, Emmanuel Wassermann Moraes

L-Carnitine and DNA

0 - Default Title
Description
L-carnitine (LC) is a quaternary amine that plays a fundamental role in cellular energy production, as it acts in the transfer of long-chain free fatty acids from the cytosol to the mitochondria, facilitating their oxidation and the production of adenosine triphosphate (ATP). In order to evaluate the antioxidant, genotoxic, and antigenotoxic activities of LC in mice, male mice were used in the experiment and divided into four groups, each with seven animals. LC was administered intraperitoneally, and lipoperoxidation (LPO) was evaluated using the TBARS method. Antioxidant activity was evaluated using the enzymes superoxide dismutase and catalase. With lower doses of L-carnitine, there were increases in SOD and CAT, and at higher doses, a decrease in these same enzymes was observed, suggesting lipid peroxidation based on the TBARS test results. LC at all doses used in the comet assay in blood and liver showed no genotoxic activity; on the other hand, it reduced oxidative damage generated by hydrogen peroxide, suggesting antigenotoxic action. Therefore, this book is intended for biologists, geneticists, and anyone who uses the comet assay for analysis.
Product details
Binding:
Paperback
Number of Pages:
76
Release Date:
2025-10-22
Publication Date:
2025-10-22
Publisher:
Our Knowledge Publishing
Languages:
Original: English
ISBN10:
6209141706
ISBN13:
9786209141706
GPSR Manufacturer Reference:
[email protected]
Weight:
131 g
Height:
150 cm
Width:
220 cm
Thickness:
5 cm
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