Recent Progress in Understanding the Mechanism and Consequences of Retrotransposon Movement

Name: Recent Progress in Understanding the Mechanism and Consequences of Retrotransposon Movement
Brand: MDPI AG
Availability: OutOfStock
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By Garfinkel, David J.

0 - Default Title

Description

Retrotransposons are present in essentially all eukaryotic genomes and come in two basic flavors: those that are bracketed by long terminal repeats (LTRs) and share a common ancestor with retroviruses, and non-LTR retrotransposons that have a distinct lineage and remain transpositionally active in humans. Both types of retrotransposons replicate through an RNA intermediate, stably integrate into the host genome and have accumulated to a very high copy number in mammals and certain plant species. Autonomous elements produce transcripts capable of undergoing reverse transcription, and minimally encode proteins with reverse transcriptase, integrase/endonucleolytic, and nucleic acid chaperone activities. Retrotransposons are currently distinguished from viruses, since the process of retrotransposition is not infectious. However, this boundary may prove to be provisional as we learn more about these mobile genetic elements. The goal of this Special Issue of Viruses is to highlight progress in understanding the mechanism and consequences of retrotransposon movement. Several active research areas may be covered in reviews and research articles, including the roles of cellular modulators and defense systems, retrotransposon expression and replication, retrotransposon-induced mutations and their association with human diseases, and how these widely disseminated elements mold eukaryotic genomes.

Product details

Binding:

Paperback

Edition:

1

Number of Pages:

202

Release Date:

2017-12-04

Publication Date:

2017-11-17

Publisher:

MDPI AG

Languages:

Original: English

ISBN10:

3038425400

ISBN13:

9783038425403

GPSR Manufacturer Reference:

[email protected]

Weight:

526 g

Height:

170 cm

Width:

244 cm

Thickness:

13 cm

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