The Hypothalamic-Pituitary-Adrenal (HPA) axis in the face of envenomation

Name: The Hypothalamic-Pituitary-Adrenal (HPA) axis in the face of envenomation
Brand: Our Knowledge Publishing
Availability: OutOfStock
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By Fares Daachi

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Description

Thehypothalamic-pituitary-adrenal(HPA)axis is a key player in the interaction between the neuroendocrine and immune systems. This study explores the impact ofAndroctonus australis hector(Aah) venom on HPA axis activation, as a function of day-night phases. Using an experimental approach, we analyze the inflammatory responses and oxidative damage induced by envenomation, highlighting the modulation exerted by corticosterone. Increased serum levels of ACTH and corticosterone indicate increased activation of the HPA, most marked during the active phase. At the same time, venom causes oxidative damage and cardio-hepatic alterations, amplified by excessive production of reactive oxygen and nitrogen species. The involvement of corticosterone in these disturbances was assessed using a dexamethasone suppression test. These results highlight an inflammatory and metabolic response modulated by circadian rhythms, underlining the importance of the HPA in the management of toxic stress.

Product details

Binding:: Paperback
Number of Pages:: 144
Release Date:: 2025-05-29
Publication Date:: 2025-05-29
Publisher:: Our Knowledge Publishing
Languages:: Original: English
ISBN10:: 6208905176
ISBN13:: 9786208905170
GPSR Manufacturer Reference:: [email protected]
Weight:: 233 g
Height:: 150 cm
Width:: 220 cm
Thickness:: 9 cm

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