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Design and Analysis of Non-Inferiority Trials

By Rothmann, Mark D.

Design and Analysis of Non-Inferiority Trials Medicine

Design and Analysis of Non-Inferiority Trials

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Description
The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Each chapter begins with a non-technical introduction, making the text easily understood by those without prior knowledge of this type of trial.
Topics covered include:
A variety of issues of non-inferiority trials, including multiple comparisons, missing data, analysis population, the use of safety margins, the internal consistency of non-inferiority inference, the use of surrogate endpoints, trial monitoring, and equivalence trials
Specific issues and analysis methods when the data are binary, continuous, and time-to-event
The history of non-inferiority trials and the design and conduct considerations for a non-inferiority trial
The strength of evidence of an efficacy finding and how to evaluate the effect size of an active control therapy
A comprehensive discussion on the purpose and issues involved with non-inferiority trials, Design and Analysis of Non-inferiority Trials will assist current and future scientists and statisticians on the optimal design of non-inferiority trials and in assessing the quality of non-inferiority comparisons done in practice.
Product details
Edition:
1
Number of Pages:
456
Release Date:
2011-07-12
Publication Date:
2011-07-12
Publisher:
Chapman and Hall/CRC
Languages:
Original: English
ISBN10:
1584888040
ISBN13:
9781584888048
GPSR Manufacturer Reference:
[email protected]
Weight:
845 g
Height:
161 cm
Width:
240 cm
Thickness:
29 cm
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