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Polyglutamine Disorders

By Nobrega Clevio Nobrega

Polyglutamine Disorders

By Nobrega Clevio Nobrega

0 - Default Title
Description
Clinical features of Huntington's disease.- Genetic rodent models of Huntington's disease.- Mitochondrial dysfunction in Huntington's disease.- RNA related pathology in Huntington's disease.- Spinal and bulbar musar atrophy: from clinical genetic features and molear pathology to mechanisms underlying disease toxicity.- Spinocerebellar Ataxia Type 1: Molear Mechanisms Of Neurodegeneration And Preclinical Studies.- Spinocerebellar Ataxia, type 6.- Spinocerebellar ataxia type 2.- Molear mechanisms and therapeutic strategies in Spinocerebellar ataxia type 7.- Spinocerebellar ataxia type 17 (SCA17).- The neuropatholy of spinocerebellar ataxia type 3/Machado-Joseph disease.- Origins and spread of Machado-Joseph disease ancestral mutational events.- Clinical features in Machado-Joseph disease.- Polyglutamine-independent features in ataxin-3 aggregation and pathogenesis of Machado-Joseph disease.- Animal models in Machado-Joseph disease.- Towards the identification of molear biomarkers of Spinocerebellar ataxia type 3/Machado-Joseph disease.- Planning future clinical trials for Machado Joseph Disease.- Molear mechanisms and cellular pathways implicated in Machado-Joseph disease pathogenesis.- Pharmacological therapies for Machado-Joseph disease.- Gene therapy for Polyglutamine diseases.- Stem cell-based therapies for Polyglutamine diseases.
Product details
Binding:
Paperback
Number of Pages:
480
Release Date:
2018-03-06
Publication Date:
2018-03-06
Publisher:
Springer Nature B.V.
Languages:
Published: English, Original: English
ISBN10:
3319717804
Weight:
668 g
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