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Epigenetics, Nuclear Organization & Gene Function

By Lucchesi, John C.

Epigenetics, Nuclear Organization & Gene Function

By Lucchesi, John C.

0 - Default Title
Description
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine.
This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.
Product details
Binding:
Paperback
Edition:
illustrated
Number of Pages:
306
Release Date:
2019-01-15
Publication Date:
2019-03-09
Publisher:
OXFORD UNIV PR
Languages:
Original: English
ISBN10:
0198831218
ISBN13:
9780198831211
GPSR Manufacturer Reference:
[email protected]
Weight:
596 g
Height:
189 cm
Width:
246 cm
Thickness:
17 cm
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