Organic synthesis of heterocyclic 1,4-benzoxazepines

Name: Organic synthesis of heterocyclic 1,4-benzoxazepines
Brand: Our Knowledge Publishing
Availability: OutOfStock
Rating: 5 (1 reviews)

By Brahim El Ghmari

0 - Default Title

Description

This study focuses on the reactivity of 2 -aminobenzylalcohol with respect to geminalized epoxides (dicyano and cyano-ester) behaving as bi-electrophiles. The method enables highly efficient synthesis of 1,4-benzoxazepin-3-ones in very high yield, thanks to simple epoxide opening followed by cyclization. All products are characterized in minute detail by NMR, mass spectrometry and Fourier Transform Infrared spectrometry (FT-IR). With cyano-esters (2), the method enables the production of novel 1,4-benzoxazepines via an efficient one-pot reaction, without catalyst. Simple to perform, selective and achievable under mild conditions, this method opens up new prospects in medicinal chemistry, with the aim of designing new bioactive compounds.

Product details

Binding:: Paperback
Number of Pages:: 52
Release Date:: 2026-01-23
Publication Date:: 2026-01-23
Publisher:: Our Knowledge Publishing
Languages:: Original: English
ISBN10:: 6209563295
ISBN13:: 9786209563294
GPSR Manufacturer Reference:: [email protected]
Weight:: 96 g
Height:: 15 cm
Width:: 22 cm
Thickness:: 0.4 cm

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