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Proteomics for Drug Discovery

By Josip Blonder

Proteomics for Drug Discovery

By Josip Blonder

0 - Default Title
Description
This detailed volume explores a wide range of experimental and bioinformatic proteomics methods applicable to the drug discovery process. Focused on drug target discovery, validation, characterization, and quantitation, the book delves into bottom-up data-dependent (DDA) shotgun and data-independent acquisition (DIA) proteomics, cell surface proteomics, proteogenomics, chemoproteomics, methodologies focused on posttranslational modifications, single cell proteomics, 3D cell culture proteomics, organoids, and laser capture microdissection (LCM) assisted tissue proteogenomics. Advanced quantitative techniques, which include label-free, mass tagging, and targeted immuno-MRM proteomics, along with top-down proteomics for validation and characterization of selected protein targets, are also described. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding foreseeable pitfalls.

Authoritative and practical, Proteomics for Drug Discovery serves as an ideal guide for researchers striving to push the field of drug discovery via MS-based proteomics to new frontiers.
Product details
Binding:
Paperback
Number of Pages:
328
Release Date:
2025-07-26
Publication Date:
2025-07-26
Publisher:
Humana
Languages:
Original: English
ISBN10:
1071639242
ISBN13:
9781071639245
GPSR Manufacturer Reference:
[email protected]
Weight:
619 g
Height:
178 cm
Width:
254 cm
Thickness:
18 cm
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