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Unclassifiable Leukemias

Unclassifiable Leukemias Medicine

Unclassifiable Leukemias

0 - Default Title
Description
Jean BERNARD * I should like to begin with an assumption and a paradox. The assumption is that leukemia is a disease of a stem cell characterized by pathologie alterations of that cell and its progeny. All present research and discussions are centered around the leukemic cell. So is this symposium, which would not take place except for our primary interest in the leukemic cell. This does not preclude, of course, consideration of other definitions and other approaches to the prOblem. By definition, then, the leukemic cells are abnormal cells and their metabolism and functions are presumed to be abnormal. Yet, the classification of the different types of leukemias is based upon the characteristics of normal cells. We talk of "lymphoblasts" and "myeloblasts" as predominant cell types in leukemia. This leads to a double paradox. In the first pi ace it is clearly illogical to classify abnormal cells by their resemblance to normal cells, since their very abnormality consists in not being normal. Yet, as a second paradox, the classifica­ ti on has had the happy consequence of ai ding us in the treatment and prognosis of leukemia for the past 25 years. A more detailed analysis shows that the consequence of this paradox are complex: while there exists a useful correlation between cellular types, treatment and prognosis, numerous problems and difficulties persist. The most serious of them concems the "unclassified leukemias" which are the reason for this reunion.
Product details
Binding:
Paperback
Edition:
1
Number of Pages:
284
Release Date:
1975-01-01
Publication Date:
1975-11-01
Publisher:
Springer
Languages:
Original: English
ISBN10:
354007242X
ISBN13:
9783540072423
GPSR Manufacturer Reference:
[email protected]
Weight:
495 g
Height:
170 cm
Width:
244 cm
Thickness:
16 cm
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