Role of Epigenetic in Cancer Biology, in Hematologic Malignancies and in Anticancer Therapy

Name: Role of Epigenetic in Cancer Biology, in Hematologic Malignancies and in Anticancer Therapy
Brand: Eliva Press
Availability: OutOfStock
Rating: 5 (1 reviews)

By Nwabo Kamdje, Armel Hervé

0 - Default Title

Description

B-cell chronic lymphocytic leukemia (CLL) is a type of cancer of the blood and bone marrow and the most common form of leukemia in adults. It's characterized by the accumulation of small, mature-appearing neoplastic lymphocytes in the blood, marrow, and secondary lymphoid tissues. The major signaling pathways involved in the tumorigenesis and in the resistance to the various anticancer therapies includes Notch, Hedgehog, and Wnt. Indeed, Notch signaling which regulates cell-fate determination during development and maintains adult tissue homeostasis was found recurrently mutated in CCL;about Wnt signaling,it also regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development and the Wnt/PCP pathway contributes to numerous aspects of CLL pathogenesis. Concerning Hedgehog, It exerts its biological effects through a signaling cascade that culminates in a change of balance between activator and repressor forms of glioma-associated oncogene (Gli) transcription factorsand its inappropriate activation occurs in several human cancers, including hematological neoplasms.

Product details

Binding:: Paperback
Number of Pages:: 64
Release Date:: 2024-09-25
Publication Date:: 2024-07-14
Publisher:: Eliva Press
Languages:: Original: English
ISBN10:: 9999320341
ISBN13:: 9789999320344
Weight:: 108 g
Height:: 152 cm
Width:: 229 cm
Thickness:: 4 cm

Buy on Amazon

Currently sold out

Add to Wishlist