Natural Compounds and Nanoformulations for Cisplatin Kidney Injury

Name: Natural Compounds and Nanoformulations for Cisplatin Kidney Injury
Brand: Scholars' Press
Availability: OutOfStock
Rating: 5 (1 reviews)

By El-Bana, Mona Anwar Mohamed

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Description

Cisplatin-induced acute kidney injury remains a major clinical challenge due to its multifactorial pathogenesis involving oxidative stress, inflammation, apoptosis, and fibrosis. Growing evidence supports the nephroprotective potential of natural compounds such as wheat germ oil, Moringa oleifera, Ficus carica, resveratrol, omega-3 polyunsaturated fatty acids, and curcumin. These agents exhibit antioxidant, anti-inflammatory, anti-apoptotic, and anti-fibrotic properties through mechanisms including activation of the Nrf2 pathway, inhibition of NF-¿B and pro-inflammatory cytokines, and preservation of renal architecture. Enhanced efficacy has been achieved through nanotechnology-based delivery systems-such as nanoemulsions, gold nanoparticles, and HA-coated carriers-which improve bioavailability and renal targeting. Collectively, these natural compounds, particularly in nanoform, offer a promising, safe, and multi-targeted therapeutic approach to mitigate cisplatin-induced AKI without compromising its antitumor effects, warranting further clinical investigation.

Product details

Binding:: Paperback
Number of Pages:: 56
Release Date:: 2025-05-23
Publication Date:: 2025-05-23
Publisher:: Scholars' Press
Languages:: Original: English
ISBN10:: 620884696X
ISBN13:: 9786208846961
Weight:: 102 g
Height:: 150 cm
Width:: 220 cm
Thickness:: 4 cm

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