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Microglia and opioid withdrawal

By Anabel Herreros Fernandez

Microglia and opioid withdrawal Law

Microglia and opioid withdrawal

0 - Default Title
Description
Drug addiction is a neurological disorder characterized by compulsive use and relapse. The use of opioids to treat pain has become a global health problem due to their abuse. Current therapies act on neurons, but have not reduced relapses, highlighting the need for new therapeutic targets. Since drugs alter glial function, microglia could represent a promising target. This study evaluated their involvement in the ventral tegmental area (VTA) and prefrontal cortex (PFC) in aversive behaviors associated with opioid withdrawal syndrome by analyzing the expression of the marker IBA-1. The conditioned place aversion (CPA) paradigm and a reconditioning protocol were used as a behavioral therapy model. The results showed a mild microglial activation in the VTA during withdrawal, which partially disappears after extinction, suggesting microglia as a possible therapeutic target in addiction.
Product details
Binding:
Paperback
Number of Pages:
52
Release Date:
2025-11-26
Publication Date:
2025-11-26
Publisher:
Our Knowledge Publishing
Languages:
Original: English
ISBN10:
6209314023
ISBN13:
9786209314025
Weight:
96 g
Height:
150 cm
Width:
220 cm
Thickness:
4 cm
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