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Molecular Mechanisms Underlying Neurotransmitter Release

By Parivash Hafez Amini

Molecular Mechanisms Underlying Neurotransmitter Release

By Parivash Hafez Amini

0 - Default Title
Description
Neural signal transmission in the central and peripheral nervous systems relies on a complex and precise event at axonal terminals of neurons, where synaptic vesicles containing neurotransmitter molecules fuse with the presynaptic membrane and release their contents into the synaptic cleft. This rapid and accurate process results from the dynamic coordination of a specialized set of proteins, each playing a vital role in recognition, docking, fusion, and release.Among these molecules, the SNARE protein family-including synaptobrevin (VAMP), syntaxin, and SNAP-25-possesses a sophisticated and specialized structure composed of ¿-helical regions. During membrane fusion, they form a four-helix bundle complex, bringing the two lipid bilayers closer together and facilitating vesicle-neuronal membrane fusion.Synaptotagmin, a calcium-binding protein, contains two C2 domains (C2A and C2B) that selectively bind calcium ions and phospholipids. Acting as a calcium sensor, it responds to sudden increases in intracellular calcium levels and triggers vesicle fusion.Synaptophysin, a four-transmembrane domain protein, is primarily known as a marker of synaptic vesicles.
Product details
Binding:
Paperback
Number of Pages:
120
Release Date:
2025-10-27
Publication Date:
2025-10-27
Publisher:
LAP LAMBERT Academic Publishing
Languages:
Original: English
ISBN10:
6209095135
ISBN13:
9786209095139
GPSR Manufacturer Reference:
[email protected]
Weight:
197 g
Height:
150 cm
Width:
220 cm
Thickness:
8 cm
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