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Evaluation of Estriol

By Alam, Md Naushad

Evaluation of Estriol

By Alam, Md Naushad

- Default Title
Description
The effect of estriol, the third estrogen, was evaluated for its effect on pentylenetetrazole (PTZ)-kindling model of epileptogenesis in mice followed by evaluation on kindling-induced changes in cognitive and motor functions. Kindling was induced by once every 2 days treatment with PTZ (25 mg/kg, i.p.) for 5 weeks. The seizure severity during induction of kindling and percentage incidence of animals kindled at the end of 5 weeks was recorded. Motor function was assessed using a grip strength meter while spatial memory was assessed in a cross maze. Estriol (0.005 and 0.01 mg/kg i.p.) reduced the time for induction of kindling from 5 weeks to 3 and 2 weeks for male and female mice respectively and enhanced the percentage incidence of seizures. Clomiphene (0.9 mg/kg i.p.) delayed the development of kindling and produced anticonvulsant effects. It also partially reversed the proconvulsant effects of estriol. On grip strength test and spontaneous alternation behaviour, a significant decline was observed in kindled mice which was further reduced by pre-treatment with estriol.
Product details
Binding:
Paperback
Number of Pages:
80
Release Date:
2026-01-12
Publication Date:
2026-01-12
Publisher:
LAP LAMBERT Academic Publishing
Languages:
Original: English
ISBN10:
6209428215
ISBN13:
9786209428210
Weight:
137 g
Height:
150 cm
Width:
220 cm
Thickness:
5 cm
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