Placeholder text

Go to cart

Colon-Targeted Therapies Using Co-Amorphous Systems

By Bhagwat, Ajay Ashok

Colon-Targeted Therapies Using Co-Amorphous Systems

By Bhagwat, Ajay Ashok

0 - Default Title
Description
The colon has emerged as a critical target site for the delivery of therapeutic agents, not only for the local treatment of diseases such as ulcerative colitis, Crohn's disease, and colorectal cancer but also for the systemic delivery of peptides, proteins, and other drugs that degrade in the upper gastrointestinal (GI) tract. As challenges persist in achieving site-specific delivery and ensuring drug stability and bioavailability in the dynamic environment of the GI tract, the development of novel formulation strategies is of paramount importance. Co-Amorphous Pellets for Colon Targeted Delivery presents a timely and comprehensive exploration of a promising formulation approach at the intersection of material science, pharmaceutics, and drug delivery technology.This book delves deeply into the innovative use of co-amorphous drug systems, a relatively new but rapidly advancing field formulated into pelletised dosage forms designed specifically for colon-targeted delivery. Co-amorphous systems, in which an active pharmaceutical ingredient (API) is stabilised in its amorphous form via molecular interactions with a small molecule co-former, offer a powerful alternative to traditional solid dispersions or crystalline drug forms. By preventing recrystallisation and improving drug solubility and dissolution rates, co-amorphous systems can dramatically enhance the therapeutic performance of poorly water-soluble drugs. In a time when personalised and targeted drug delivery is gaining increasing importance, this book contributes to a deeper understanding of co-amorphous systems and their vast potential in addressing solubility and targeting challenges. It provides a strong foundation and practical guidance for developing next-generation colon-targeted therapies using co-amorphous pellet formulations.
Product details
Binding:
Paperback
Number of Pages:
84
Release Date:
2025-07-12
Publication Date:
2025-12-05
Publisher:
Eliva Press
Languages:
Original: English
ISBN10:
9999328881
ISBN13:
9789999328883
Weight:
136 g
Height:
152 cm
Width:
229 cm
Thickness:
5 cm
Buy on Amazon
Currently sold out