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Matrix Metalloproteinase

By Ågren, Magnus S

Product Image: Matrix Metalloproteinase

Matrix Metalloproteinase

By Ågren, Magnus S

- Default Title
Description
Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.
Product details
Number of Pages:
262
Release Date:
2020-08-31
Publication Date:
2020-08-31
Publisher:
MDPI AG
Languages:
Original: English
ISBN10:
3039366483
ISBN13:
9783039366484
GPSR Manufacturer Reference:
[email protected]
Weight:
855 g
Height:
175 cm
Width:
250 cm
Thickness:
22 cm
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