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Phase I Cancer Clinical Trials

By Eisenhauer, Elizabeth A

Phase I Cancer Clinical Trials

By Eisenhauer, Elizabeth A

- Default Title
Description
Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule and pharmacologic behavior of new agents or new combinations of agents and to describe the adverse effects of treatment. In cancer therapeutics, such studies have particular challenges. Due to the nature of the effects of treatment, most such studies are conducted in patients with advanced malignancy, rather than in healthy volunteers. Further, the endpoints of these trials are usually measures adverse effects rather than molecular target or anti-tumor effects. These factors render the design, conduct, analysis and ethical aspects of phase I cancer trials unique. As the only comprehensive book on this topic, Phase I Cancer Clinical Trials is a useful resource for oncology trainees or specialists interested in understanding cancer drug development. New to this edition are chapters on Phase 0 Trials and Immunotherapeutics, and updated information on the process, pitfalls, and logistics of Phase I Trials
Product details
Binding:
Paperback
Edition:
2
Number of Pages:
370
Release Date:
2015-04-17
Publication Date:
2015-04-01
Publisher:
Oxford University Press
Languages:
Original: English
ISBN10:
0199359016
ISBN13:
9780199359011
GPSR Manufacturer Reference:
[email protected]
Weight:
562 g
Height:
156 cm
Width:
234 cm
Thickness:
20 cm
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