{"product_id":"radka-snajdrova-asymmetric-baeyer-villiger-oxidations-using-biocatalysts-9783639192650","title":"Asymmetric Baeyer-Villiger Oxidations Using Biocatalysts.","description":"Chiral lactones are important building blocks in organic synthesis. A broad range of useful products are accessible via enantioselective Baeyer-Villiger oxidation of simple ketones. Such lactones can serve as versatile building blocks in natural product and bioactive compound synthesis.For the transformation of achiral ketones to chiral lactones, Baeyer-Villiger monooxygenases (BVMOs) were utilized, since these enzymes exhibit wide substrate specificity and high enantioselectivity. The advantage of this approach is that BVMOs can generate several chiral centers in a single biotransformation step. Various cofactor recycling options have also been considered during this study. As a direct consequence of this research, a metabolically independent biocatalyst was developed, which performs cofactor regeneration concomitantly with the oxygenation reaction. . Such a system is very attractive for industrial applications as operational costs are dramatically reduced due to the absence for the requirement of co-factor recycling.","brand":"VDM Verlag Dr. Müller e.K.","offers":[{"title":"Default Title","offer_id":53687932027222,"sku":null,"price":0.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0925\/5829\/5382\/files\/product_image_9783639192650_1_13dad588-e980-4064-8ed4-bb258de9e7c2.jpg?v=1781747756","url":"https:\/\/www.momoxbooks.com\/products\/radka-snajdrova-asymmetric-baeyer-villiger-oxidations-using-biocatalysts-9783639192650","provider":"momoxbooks","version":"1.0","type":"link"}