{"product_id":"krishna-prakash-murine-interferon-regulatory-factor-2-irf-2-and-escherichia-coli-9786209184550","title":"Murine Interferon Regulatory Factor-2 (IRF-2) and Escherichia coli","description":"Interferon Regulatory Factor-2 is a vertebrate transcription factor having oncogenic nature; it antagonises Interferon Regulatory Factor-1, a tumor suppressor gene, functions. Knockout mice for IRF-2 gene showed defect in B-cell lymphopoeisis, they died following LCMV (Lymphocytic Choriomeningitis Virus) infections. IRF-2 is functionally just opposite of IRF-1. Interestingly, one would have thought that as IRF-1-\/- (knock-out) mice showed lack of CD8+T cells and low cytotoxicity of NK cells, the over production of IRF-2 in mice may restore it. But it does not happen so, the reason being unknown. However, IRF-2 binds at Interferon Stimulated Response Element sequence in viral infected cell. This book is about mouse IRF-2 gene cDNA cloning and expression of chimeric protein in E.coli. This study will serve as a platform for further functional analysis of chimeric IRF-2, which is potent oncogene in aberrant conditions.","brand":"LAP LAMBERT Academic Publishing","offers":[{"title":"Default Title","offer_id":53768949432662,"sku":null,"price":0.0,"currency_code":"EUR","in_stock":false}],"url":"https:\/\/www.momoxbooks.com\/products\/krishna-prakash-murine-interferon-regulatory-factor-2-irf-2-and-escherichia-coli-9786209184550","provider":"momoxbooks","version":"1.0","type":"link"}