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Systemic protective responses to intranasal endotoxin application

By Irina Tselkova

Systemic protective responses to intranasal endotoxin application

By Irina Tselkova

0 - Default Title
Description
This monograph presents the results of studies aimed at identifying the mechanisms controlling deep body temperature, metabolic intensity, behavioral activity, and nociceptive responses in rats following the application of Escherichia coli endotoxin to the nasal mucosa. The study proves for the first time that E. coli endotoxin penetrates the brain of laboratory rats after intranasal application, accompanied by a single- or two-phase rise in core body temperature, shifts in the intensity of metabolic processes, wave-like changes in behavioral activity, and the severity of nociceptive reactions. Based on the data obtained, an experimental model of the systemic inflammatory process was developed, initiated by the application of Escherichia coli endotoxin to the mucous membrane of the nasal cavity of rats. The model allows studying the mechanisms of the development of the systemic inflammatory process under conditions of natural contact of living organisms with lipopolysaccharides.
Product details
Binding:
Paperback
Number of Pages:
132
Release Date:
2025-11-23
Publication Date:
2025-11-23
Publisher:
Our Knowledge Publishing
Languages:
Original: English
ISBN10:
6209260004
ISBN13:
9786209260001
GPSR Manufacturer Reference:
[email protected]
Weight:
215 g
Height:
150 cm
Width:
220 cm
Thickness:
9 cm
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