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New Trends In Chemotherapy

By Nassar, Ibrahim F.

New Trends In Chemotherapy

By Nassar, Ibrahim F.

0 - Default Title
Description
The contemporary work depicts synthesizing an innovative sequence of polyfunctionalized Pyrazolo[3,4-b]pyridine congeners ES1-ES18 and assessed for antimicrobial, antitumor, telomerase inhibition, and Anti-hepatitis B efficacies applying an array of techniques. Fortunately, most of the compounds demonstrated auspicious bio efficiencies. Additionally, in silico simulation was executed for determining the synthetic Pyrazolo[3,4-b]pyridines anticipated mode of action. Compounds ES4, ES5, and ES6 were picked as the most potent and efficient candidates versus the telomerase enzyme [PDB id: 2B2A]. The consequences exposed that compound ES5 is the extremely credible operative in contradiction of telomerase enzyme as it disclosed the best binding score and interaction pose. These initial outcomes may improve in introducing more research strategies converged on pyrazolo[3,4-b]pyridines, exclusively those with anticipated bioefficacy, ultimate ADMET parameters, and constructive prospects.
Product details
Binding:
Paperback
Number of Pages:
58
Release Date:
2024-09-18
Publication Date:
2024-07-14
Publisher:
Eliva Press
Languages:
Original: English
ISBN10:
9999320287
ISBN13:
9789999320283
Weight:
100 g
Height:
152 cm
Width:
229 cm
Thickness:
4 cm
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