{"product_id":"brahim-el-ghmari-organic-synthesis-of-heterocyclic-1-4-benzoxazepines-9786209563294","title":"Organic synthesis of heterocyclic 1,4-benzoxazepines","description":"This study focuses on the reactivity of 2 -aminobenzylalcohol with respect to geminalized epoxides (dicyano and cyano-ester) behaving as bi-electrophiles. The method enables highly efficient synthesis of 1,4-benzoxazepin-3-ones in very high yield, thanks to simple epoxide opening followed by cyclization. All products are characterized in minute detail by NMR, mass spectrometry and Fourier Transform Infrared spectrometry (FT-IR). With cyano-esters (2), the method enables the production of novel 1,4-benzoxazepines via an efficient one-pot reaction, without catalyst. Simple to perform, selective and achievable under mild conditions, this method opens up new prospects in medicinal chemistry, with the aim of designing new bioactive compounds.","brand":"Our Knowledge Publishing","offers":[{"title":"Default Title","offer_id":53821069787478,"sku":null,"price":0.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0925\/5829\/5382\/files\/product_image_9786209563294_1_ab6eb616-def7-426f-a78f-6556f937c48a.jpg?v=1783426416","url":"https:\/\/www.momoxbooks.com\/products\/brahim-el-ghmari-organic-synthesis-of-heterocyclic-1-4-benzoxazepines-9786209563294","provider":"momoxbooks","version":"1.0","type":"link"}