{"product_id":"ameni-jerbi-th17-cytokine-gene-polymorphism-9786208972356","title":"Th17 cytokine gene polymorphism","description":"Hemorrhagic rectocolitis (UC) and Cohn's disease (CD), the two main forms of chronic inflammatory bowel disease (IBD), result from an inappropriate immune response to the intestinal flora in a genetically predisposed individual in the presence of environmental factors. IBD is a complex pathology associated with chronic inflammation of the intestine, in which helper T lymphocytes (THL) appear to be heavily involved.Currently, the Th17 subpopulation is described as the main player in local inflammation via pro-inflammatory cytokines (IL 17, 21 and 22). IL-17A and IL-17F are the 2 main effector cytokines, sharing over 50% homology in terms of amino acid sequence. The corresponding genes are located close to each other on the short arm of chromosome 6 (6p12). We studied the genetic polymorphism of 2 genes involved in the Th17 pathway: IL-17A (rs3748067) and IL-17F (rs763780) in a group of Tunisian IBD patients compared with a control group.","brand":"Our Knowledge Publishing","offers":[{"title":"Default Title","offer_id":53703319716182,"sku":null,"price":0.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0925\/5829\/5382\/files\/product_image_9786208972356_1_a78fbb25-dcbf-47b2-8881-62281d4873a9.jpg?v=1778867766","url":"https:\/\/www.momoxbooks.com\/products\/ameni-jerbi-th17-cytokine-gene-polymorphism-9786208972356","provider":"momoxbooks","version":"1.0","type":"link"}