{"product_id":"ameni-jerbi-immunological-investigation-of-autoimmune-bullous-dermatoses-9786208187873","title":"Immunological investigation of autoimmune bullous dermatoses","description":"Autoimmune bullous dermatoses (ABD) are specific autoimmune diseases of the skin and mucous membranes. They are characterized by the presence of autoantibodies (auto-Ab) directed against skin and mucous membrane adhesion molecules, leading to altered function of their antigenic targets, resulting in clinical bullae and\/or erosions. Depending on the site of cleavage, a distinction is made between intra-epidermal DBAI, characterized by auto-Ac directed against the structural proteins of the desmosomes that hold the keratinocytes of the epidermis together; and sub-epidermal DBAI, characterized by the presence of auto-Ac directed against the components of the dermo-epidermal junction (DEJ).The diagnosis of DBAI is based on clinical, histopathological and immunological evidence (detection of circulating or tissue-deposited auto-Ac). Direct immunofluorescence (DIF) is an immunological technique performed on cryosections of peri-lesional biopsies, based on the detection of Ac deposits and\/or complement fractions using specific fluorescein-conjugated Ac.","brand":"Our Knowledge Publishing","offers":[{"title":"Default Title","offer_id":53756172403030,"sku":null,"price":0.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0925\/5829\/5382\/files\/product_image_9786208187873_1.jpg?v=1781796132","url":"https:\/\/www.momoxbooks.com\/products\/ameni-jerbi-immunological-investigation-of-autoimmune-bullous-dermatoses-9786208187873","provider":"momoxbooks","version":"1.0","type":"link"}